SEXUAL DIFFERENCES IN BLOOD PRESSURE REGULATION AND HYDROSALINE HOMEOSTASIS
Although there are evidences that highlight and analyze sex differences in cardiovascular disease, to date most of studies have been carried out in men, with the idea that males and females are similar, differing only in the magnitude of the response. However, principles learned in male models cannot and should not be extrapolated to women and, therefore, it is important to study in greater detail not only the differences between the sexes but also the physiological intertwining of the underlying genetic and hormonal mechanisms of sexual dimorphism.
Clinical and experimental studies have provided evidence that, during sensitive periods of ontogeny, certain perinatal stimuli induce differential “programming” effects on various homeostatic systems; altering their response even during adulthood. Thus, adverse experiences in the early stages of life may have a long-term multisystemic impact on the individual, for which early exposure to stress has been identified as an important risk factor for the development of cardiovascular diseases later in life. Based on this evidence, we have recently incorporated another line of work in which we propose to analyze the effect of early maternal separation, in adult offspring, in the regulation of blood pressure and hydrosaline homeostasis; analyzing in particular the intervening hormonal and genetic factors involved in the sexually dimorphic responses.
More detailed understanding of the sources of physiological disparities between the sexes may help in understanding the differences between the sexes in rates of cardiovascular disease, and may also aid in designing future improvements for sex-tailored therapeutic treatments.
COMPETITIVE RESEARCH FUNDS
- PICT-2018- 03361. Agencia Nacional de Promoción Científica y Tecnológica, FONCyT. Tema: Dimorfismo sexual en la respuesta vasopresinérgica antidiurética y presora. Investigadora Responsable.
- 2021-2023. PIP CONICET GI Programación perinatal del sistema vasopresinérgico: efectos psicofisiológicos y sexualmente dimórficos. Rol: grupo colaborador.
PUBLICATIONS (LATEST FIVE YEARS)
- Caeiro XE, Silva GV, Godino A. Sex Differences in Autonomic Blood Pressure Regulation: Sex Chromosome Complement and Hormonal Involvement. Review. Sexes 2023, 4(4), 536-554; https://doi.org/10.3390/sexes4040035
- Porcari CY, Macagno A, Mecawi AS, Anastasía A, Caeiro XE, Godino A. Effects of Voluntary Sodium Consumption during the Perinatal Period on Renal Mechanisms, Blood Pressure, and Vasopressin Responses after an Osmotic Challenge in Rats. Nutrients. 2023;15(2):254. doi:10.3390/nu15020254
- Porcari CY, Cambiasso MJ, Mecawi AS, Caeiro XE, Antunes-Rodrigues J, Vivas L, Godino A. Molecular neurobiological markers in the onset of sodium appetite. Sci Rep. 2022;12(1):14224. doi:10.1038/s41598-022-18220-w
- Porcari CY, Debarba LK, Amigone JL, Caeiro XE, Reis LC, Cunha TM, Mecawi AS, Elias LL, Antunes-Rodrigues jJ, Vivas L, Godino A. Brain osmo-sodium sensitive channels and the onset of sodium appetite. Horm Behav. 2020;118:104658. doi:10.1016/j.yhbeh.2019.104658
- Porcari CY, Araujo IG, Urzedo-Rodrigues L, , De Luca Jr LA, Vanderlei Menani J, Caeiro XE, Imboden H, Antunes-Rodrigues J, Reis LC, Vivas L, Godino A, Souza Mecawi A. Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus. J Neuroendocrinol. 2019;31(4):e12703. doi:10.1111/jne.12703
TEAM
