Role of parenting and attachment on neurodevelopment and responses to alcohol in infants and adolescents.
Filial bonds play an important role in the development of offspring. Different social experiences and attachment conditions during early development and throughout life can directly affect drug use and abuse. This becomes relevant considering that the interactions between drugs of abuse and social behaviors have led to the hypothesis that the neural circuits involved in the reinforcing effects of these drugs would be shared by those underlying natural reinforcers, among them, social attachment. The general objective of the project is to analyze, through the use of an animal model, the role of family structure and attachment, during early ontogeny, on the neurodevelopment of the progeny and on the response to alcohol. The execution of this project will allow us to answer some questions in the current literature, allowing us to investigate the role that each parent has in different parenting models and their effects on subsequent reactivity to alcohol, both in the parents and in their progeny.
COMPETITIVE RESEARCH FUNDS
- 2021 – 2024 PICT-2019-00574, financiado por la Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). “Impacto de la estructura familiar y la crianza durante el desarrollo temprano sobre la reactividad frente al alcohol”. Director.
- 2021 – 2024. PICT-2019-00827, financiado por ANPCyT. “Exposición Etílica en Fetos e Infantes Altriciales: Efectos sobre la Reactividad al Alcohol (Continuación).”
- 2018 – 2022. CONSOLIDAR SECyT-UNC “Exposición etílica temprana: adquisición de aprendizajes con impacto sobre la reactividad respiratoria y procesos de sensibilización a la droga (continuación)” IR: Juan C. Molina.
- 2017-2019. PICT-2016-2461. Proyecto financiado por la Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). “Impacto de la estructura familiar y el apego durante el desarrollo temprano sobre la reactividad frente al alcohol”.
PUBLICATIONS (LATEST FIVE YEARS)
- Salguero A, Barey A, Virgolini RG, Mujica V, Fabio MC, Miranda-Morales RS, Marengo L, Camarini R, Pautassi RM. Juvenile variable stress modulates, in female but not in male Wistar rats, ethanol intake in adulthood. Neurotoxicology and Teratology. (2023) 4:107306. doi: 10.1016/j.ntt.2023.107306
- Ferreyra EA, Pasquetta LM, Ramirez A, Wille-Bille A, Molina JC, Miranda-Morales RS. Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption. Psychopharmacology (Berl) (2020). 237(6):1841-1850 doi: 10.1007/s00213-020-05501-3
- Miranda-Morales RS, D’aloisio G, Anunziata F, Abate P, Molina JC. Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies. Frontiers in Behavioral Neuroscience (2020). 14, 33. doi: 10.3389/fnbeh.2020.00033
- Wille-Bille A, Bellia F, Jiménez García AM, Miranda-Morales RS, D’Addario C, Pautassi RM. Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake. Neuropharmacology (2020). 165, 107917. doi: 10.1016/j.neuropharm.2019.107917.
- Complete and updated list available here.
TEAM
