The main dysfunctions in sodium and body water balance are classically recognized as hyponatraemia and hypernatraemia because sodium is the ion determining the osmolarity of the extracellular fluid. Both disorders contribute to morbidity and mortality and are highly prevalent in critically ill patients. Hyponatraemia is recognized as the most common electrolyte disorder in clinical medicine. Epidemiological studies have indicated that hyponatraemia occurs in approximately 1-2% of hospitalized patients. In this regard, previous work by our and other laboratories has shown that hyponatraemia caused by acute body sodium depletion generates a state of hypovolaemia, which stimulates the renin angiotensin aldosterone system (RAAS). This system is one of the main corrective mechanisms, as it promotes renal sodium and water retention and stimulates water and sodium intake, known as thirst and sodium appetite respectively. However, it has been reported that there is a temporal dissociation between the fall in plasma natraemia/osmolarity and the onset of the corrective behavior, sodium appetite, which is stimulated with a latency of between 16 h to days depending on the model under study.
In contrast, states of hypernatremia and body hyperosmolarity are associated with the development of cardiovascular diseases such as hypertension in genetically predisposed individuals or kidney disease. There is a large consensus on the effect of habitual and excessive salt consumption in Western societies on blood pressure. It has also recently been shown that maternal sodium intake during the perinatal period is capable of determining and/or programming blood pressure regulation in the next generation. In this regard, our results, in an animal model, indicate that early exposure to a hypernatremic environment is able to alter in offspring during adulthood: -water and sodium intake; -salt preference; -the activity of various brain areas, -the synthesis of components of the vasopressin and angiotensin systems at the brain and renal level; and blood pressure regulation, in the face of various osmotic challenges.
COMPETITIVE RESEARCH FUNDS
- 2023-2026. PICT-2021-GRF-TII-00234. “Efectos De La Programación Perinatal Inducida Por El Consumo Voluntario De Sal Sobre La Regulación Cardiovascular: Mecanismos Implicados”. PI
- 2021. PIP CONICET “Programación perinatal del sistema vasopresinérgico: efectos psicofisiológicos y sexualmente dimórficos”. PI: Angélica Rivarola. Researcher.
- 2020-2023. SECyT. UNC. “Efecto la exposición temprana (perinatal) a un ambiente hipersomótico sobre la regulación de la presión arterial y el mecanismo de osmoregulación central en la adultez” PI
PUBLICATIONS (LATEST FIVE YEARS)
- Ximena E. Caeiro Gabriela V. Silva Andrea Godino. Sex Differences in Autonomic Blood Pressure Regulation: Sex Chromosome Complement and Hormonal Involvement. October 2023Sexes 4(4):536-554. DOI: 10.3390/sexes4040035
- Porcari, C.Y.; Macagno, A.;Mecawi, A.S.; Anastasía, A.; Caeiro,X.E.; Godino, A. Effects of Voluntary Sodium Consumption during the Perinatal Period on Renal Mechanisms, Blood Pressure, and Vasopressin Responses after an Osmotic Challenge in Rats. Nutrients 2023, 15, 254. https://doi.org/ 10.3390/nu15020254. IF: 6.7 Q1
- Porcari CY, Cambiasso MJ, Mecawi AS, Caeiro XE, Antunes-Rodrigues J, Vivas LM, Godino A. Molecular neurobiological markers in the onset of sodium appetite. Sci Rep. 2022 Aug 20;12(1):14224. doi: 10.1038/s41598-022-18220-w. PMID: 35987984; PMCID: PMC9392805. IF:4.99 Q1
- Wille-Bille A, Marengo L, Godino A, Pautassi RM. Effects of escalating versus fixed ethanol exposure on ∆FosB expression in the mesocorticolimbic pathway in adolescent and adult rats. Am J Drug Alcohol Abuse. 2021 Aug 12:1-12. doi: 10.1080/00952990.2021.1954188. Epub ahead of print. PMID: 34383595. IF: 3.912 Q1
- Porcari C.Y. a, Debarba L.K. b,Amigone J.Lf, Caeiro X.E.a, Reis L.C.e, Cunha T.M.b, Mecawi A.S.g, Elias, L.L.b, Antunes-Rodrigues J.b, Vivas L.ac *and Godino A.ad+*. (+autor corresponsal* contribución equivalente). Brain osmo-sodium sensitive channels and the onset of sodium apetite. Horm Behav. 2020 Feb;118:104658. doi: 10.1016/j.yhbeh.2019.104658. Epub 2020 Jan 7. IF: 3.587 Q1
- Cintia Yamila Porcaria, Iracema Gome Araújob, Lilia Urzedo-Rodriguesc, Laurival Antonio De Luca Jrc, José Vanderlei Menanic, Ximena Elizabeth Caeiro, Hans Imbodend, José Antunes-Rodriguese, Luís Carlos Reisb, Laura Vivasa,f, Andrea Godino,*, André Souza Mecawi*. *Contribución equivalente. Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus. J Neuroendocrinol. 2019 Apr;31(4):e12703. doi: 10.1111/jne.12703.
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